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Racial and Genetic Risk Factors for Diabetes

From Jennifer Hicks, for About.com

Updated December 01, 2008

About.com Health's Disease and Condition content is reviewed by our Medical Review Board

(LifeWire) - There are controllable risk factors associated with diabetes, including obesity and an inactive lifestyle. However, other uncontrollable risk factors, such as ethnicity and genetics, also play roles.

How Do the Risk Factors for Diabetes Vary by Race and Ethnicity?

Although non-Hispanic whites are at greater risk of developing type 1 diabetes than other racial groups, that does not hold true for type 2 diabetes. According to 2002 statistics from the Centers of Disease Control and Prevention, Latinos, American Indians, Asian Americans and non-Hispanic blacks are twice as likely to have type 2 diabetes as non-Hispanic whites.

In addition, the types of complications experienced by people with type 2 diabetes in each racial/ethnic group can vary. For instance:

  • African Americans with diabetes have a higher percentage of end-stage renal disease than non-Hispanic whites.
  • Non-Hispanic whites have less risk of developing retinopathy (eye disease) than American Indians.
  • Asian Americans and Pacific Islanders have a lower diabetes-related death rate than any of the other groups.

How Do Genetic Factors Influence Diabetes Risk?

Genes are what give us red hair, green eyes, mahogany skin or tall stature, among a host of other traits -- including a predisposition for diabetes.

Research has shown that certain gene variations raise the risk of developing diabetes. These genes can be associated with insulin sensitivity in the body's tissues, decreased insulin production and an increased risk of obesity. Research also indicates that women who develop gestational diabetes while pregnant, and who also have GAD antibodies, are at greater risk of developing type 1 diabetes later in life.

However, genes alone are not enough to cause the disease. For instance, consider identical twins, who also have identical genes. If one twin has type 1 diabetes, the other develops it only half of the time. If one has type 2 diabetes, the other develops it no more than 75% of the time.

In addition, researchers note that lifestyle modifications -- including exercise and a healthy diet -- can reduce the risk of developing prediabetes and type 2 diabetes, even for people who have a genetic predisposition.

What Diabetes Risk Factors Can Be Controlled?

Although genes and ethnicity are risk factors for diabetes, they are not the sole determinants of whether someone develops the disease. Environment plays a role, as does lifestyle. Staying active, maintaining a healthy weight and eating a balanced diet can help postpone or prevent type 2 diabetes.

The American Diabetes Association has a risk-assessment quiz on its website, which can help you get an idea of your potential for developing diabetes. People at high risk should talk with a health care professional to see what lifestyle changes can be made to stay free of diabetes.

Sources:

"The Genetics of Diabetes." /American Diabetes Association/. American Diabetes Association. 8 Sept 2007 .

" Diabetes Disparities Among Racial and Ethnic Minorities." /Agency for Healthcare Research and Quality/. Nov 2001. U.S. Department of Health and Human Services. 8 Sept 2007 .

"National Diabetes Fact Sheet." /CDC's Diabetes Program - Publications and Products/. 2003. Centers for Disease Control and Prevention. 8 Sept 2007 .

Ehrmann D.A, K. Kasza, R. Azziz R, R. Legro, and M. N. Ghazzi. "Effects of Race and Family History of Type 2 Diabetes on Metabolic Status of Women with Polycystic Ovary Syndrome." /J Clin Endocrinol Metab/ (2005) 90:66-71. 7 Sep 2007.

Nilsson C., D. Ursing, C. Törn, A. Aberg, and M. Landin-Olsson. "Presence of GAD-antibodies During Gestational Diabetes Predicts Type 1 Diabetes." /Diabetes Care./ (2007). 4 Sep 2007.

Oldfield, M.D., P. Donley, L. Walwyn, I. Scudamore, and R. Gregory. "Long Term Prognosis of Women With Gestational Diabetes in a Multiethnic Population." /Postgrad Med J/. 83(2007): 426-30.

Retnakaran, R., P.W. Connelly, M. Sermer, B. Zinman and A.J.G Hanley. /"/The Impact of Family History of Diabetes on Risk Factors for Gestational Diabetes./"/ /Clin Endocrinol/ (Oxf) (2007). 4 Sep 2007.

Scott, Laura J., K. L. Mohlke, L.L. Bonnycastle, C. J. Willer, L. Yun Li, W. L. Duren et al. "A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants." /Science/(2007) 316: 1341 – 45.

LifeWire, a part of The New York Times Company, provides original and syndicated online lifestyle content. Jennifer Hicks has written and published more than 600 articles, primarily in the fields of health care and medicine. She is also the CEO of WordsWork Consulting, Inc., a consulting firm in the fields of health literacy and best Web practices. A former professor at Northeastern University in Boston, Jennifer has a family member who has lived with type 1 diabetes for 20 years.

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